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Subacute Sclerosing PanencephalitisLegal notice  


Other terms
Sclerosing Panencephalitis, Subacute,Panencephalitides, Subacute Sclerosing,Sclerosing Panencephalitides, Subacute,Subacute Sclerosing Panencephalitides,Panencephalitis, Subacute Sclerosing,Leukoencephalitis, Van Bogaert's,Leukoencephalitis, Van Bogaert,Leukoencephalitis, Van Bogaerts,Inclusion Body Encephalitis, Measles,Sclerosing Leukoencephalitis, Subacute,Leukoencephalitides, Subacute Sclerosing,Sclerosing Leukoencephalitides, Subacute,Subacute Sclerosing Leukoencephalitides,Subacute Sclerosing Leukoencephalitis,Leukoencephalitis, Subacute Sclerosing,Measles Inclusion Body Encephalitis,Encephaltis, Inclusion Body, Measles,SSPE,Van Bogaert's Leukoencephalitis,Van Bogaert Leukoencephalitis,Van Bogaerts Leukoencephalitis

Description
Subacute Sclerosing Panencephalitis: A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)



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