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Multiple Endocrine Neoplasia Type 2bLegal notice  


Other terms
Mucosal Neuroma Syndrome,Mucosal Neuroma Syndromes,Neuroma Syndrome, Mucosal,Multiple Endocrine Neoplasia, Type 2b,Multiple Endocrine Neoplasms Type 2b,Neoplasia, Multiple Endocrine Type 2b,Neoplasms, Multiple Endocrine Type 2b,MEN2b,MEA 2b,MEA IIb,MEN 2b,MEN 3,MEN IIb,MEN III

Description
Multiple Endocrine Neoplasia Type 2b: Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.



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Legal notice
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The version of the data is 2010 MeSH. Last reviewed April 26, 2010. No modification has been made in the content of the file.
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