Other terms
Gamstorp-Wohlfart Syndrome,Gamstorp Wohlfart Syndrome,Gamstorp-Wohlfart Syndromes,Syndromes, Gamstorp-Wohlfart,Isaacs' Syndrome,Isaac Syndrome,Isaacs-Mertens Syndrome,Isaacs Mertens Syndrome,Syndromes, Isaacs-Mertens,Syndrome of Continuous Muscle Activity,Neuromyotonia,Pseudomyotonia,Pseudomyotonia Syndrome of Isaacs,Isaacs Pseudomyotonia Syndrome,Quantal Squander,Continuous Muscle Activity Syndrome,Myokymia, Continuous,Continuous Myokymia,Continuous Myokymias,Myokymias, Continuous,Acquired Neuromyotonia,Neuromyotonia, Acquired
Description
Isaacs Syndrome: A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)
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