Other terms
Leukodystrophies, Metachromatic,Metachromatic Leukodystrophies,Metachromatic Leukodystrophy,Sulfatide Lipidosis,Lipidosis, Sulfatide,Cerebroside Sulphatase Deficiency Disease,Metachromatic Leukoencephalopathy,Leukoencephalopathies, Metachromatic,Leukoencephalopathy, Metachromatic,Metachromatic Leukoencephalopathies,Arylsulfatase A Deficiency Disease,Cerebral sclerosis, Diffuse, Metachromatic Form,Metachromatic Leukodystrophy, Infant,Infant Metachromatic Leukodystrophies,Infant Metachromatic Leukodystrophy,Metachromatic Leukodystrophies, Infant,Greenfield's Disease,Metachromatic Leukodystrophy, Infant-Type,Infant-Type Metachromatic Leukodystrophies,Infant-Type Metachromatic Leukodystrophy,Metachromatic Leukodystrophies, Infant-Type,Metachromatic Leukodystrophy, Infant Type,Greenfield Disease,Leukodystrophy, Metachromatic, Adult,Metachromatic Leukodystrophy, Adult-Type,Adult-Type Metachromatic Leukodystrophies,Adult-Type Metachromatic Leukodystrophy,Leukodystrophies, Adult-Type Metachromatic,Leukodystrophy, Adult-Type Metachromatic,Metachromatic Leukodystrophies, Adult-Type,Metachromatic Leukodystrophy, Adult Type,Leukodystrophy, Metachromatic, Juvenile,Metachromatic Leukodystrophy, Juvenile-Type,Juvenile-Type Metachromatic Leukodystrophies,Juvenile-Type Metachromatic Leukodystrophy,Leukodystrophies, Juvenile-Type Metachromatic,Leukodystrophy, Juvenile-Type Metachromatic,Metachromatic Leukodystrophies, Juvenile-Type,Metachromatic Leukodystrophy, Juvenile Type,Arylsulfatase A Deficiency,Arylsulfatase A Deficiencies,Deficiencies, Arylsulfatase A,Deficiency, Arylsulfatase A,Cerebroside Sulfatase Deficiency,Cerebroside Sulfatase Deficiencies,Deficiencies, Cerebroside Sulfatase,Deficiency, Cerebroside Sulfatase,Sulfatase Deficiencies, Cerebroside,Sulfatase Deficiency, Cerebroside
Description
Leukodystrophy, Metachromatic: An autosomal recessive metabolic disease caused by a deficiency of CEREBROSIDE-SULFATASE leading to intralysosomal accumulation of cerebroside sulfate (SULFOGLYCOSPHINGOLIPIDS) in the nervous system and other organs. Pathological features include diffuse demyelination, and metachromatically-staining granules in many cell types such as the GLIAL CELLS. There are several allelic and nonallelic forms with a variety of neurological symptoms.
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