Other terms
Lateral Scleroses, Amyotrophic,Sclerosis, Amyotrophic Lateral,Gehrig's Disease,Gehrig Disease,Gehrigs Disease,Lou-Gehrigs Disease,Disease, Lou-Gehrigs,Lou Gehrig's Disease,Motor Neuron Disease, Amyotrophic Lateral Sclerosis,ALS (Amyotrophic Lateral Sclerosis),Lou Gehrig Disease,Amyotrophic Lateral Sclerosis, Guam Form,Guam Form of Amyotrophic Lateral Sclerosis,Amyotrophic Lateral Sclerosis With Dementia,Dementia With Amyotrophic Lateral Sclerosis
Description
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
Pervious tree
Next tree
Other locations in tree
Legal notice
The U.S. National Library of Medicine is the creator, maintainer, and provider of the data above.
The version of the data is 2010 MeSH. Last reviewed April 26, 2010. No modification has been made in the content of the file.
Neither the United States Government, nor any of its agencies, contractors, subcontractors or employees makes any warranties, expressed or implied, with respect to data contained in the database, and, furthermore, assumes no legal liability for any party's use, or the results of such use, of any part of the database.
You will not assert any proprietary rights to any portion of the database, or represent the database or any part thereof to anyone as other than a United States Government database.
The MeSH data carry an international copyright outside the United States, its Territories or Possessions. These terms and conditions are in effect as long as the user retains any of the MeSH data obtained from this site.