Other terms
Autoimmune Polyendocrinopathies,Autoimmune Polyendocrinopathy,Polyendocrinopathy, Autoimmune,Polyglandular Type I Autoimmune Syndrome,Autoimmune Polyglandular Syndrome, Type 1,Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal-Dystrophy,Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy,Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal-Dystrophies,Polyendocrinopathy-Candidiasis-Ectodermal-Dystrophies, Autoimmune,Polyendocrinopathy-Candidiasis-Ectodermal-Dystrophy, Autoimmune,Polyglandular Autoimmune Syndrome, Type 1,Autoimmune Polyglandular Syndrome Type I,Autoimmune Syndrome Type I, Polyglandular,Polyglandular Type II Autoimmune Syndrome,Autoimmune Syndrome Type II, Polyglandular,Schmidt's Syndrome,Schmidt Syndrome,Schmidts Syndrome,Syndrome, Schmidt's,Autoimmune Polyglandular Syndrome Type II
Description
Polyendocrinopathies, Autoimmune: Autoimmune diseases affecting multiple endocrine organs. Type I is characterized by childhood onset and chronic mucocutaneous candidiasis (CANDIDIASIS, CHRONIC MUCOCUTANEOUS), while type II exhibits any combination of adrenal insufficiency (ADDISON'S DISEASE), lymphocytic thyroiditis (THYROIDITIS, AUTOIMMUNE;), HYPOPARATHYROIDISM; and gonadal failure. In both types organ-specific ANTIBODIES against a variety of ENDOCRINE GLANDS have been detected. The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present.
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