Other terms
miRNAs,miRNA,Micro RNA,RNA, Micro,MicroRNA,Primary MicroRNA,MicroRNA, Primary,Primary miRNA,miRNA, Primary,pri-miRNA,pri miRNA,RNA, Small Temporal,Temporal RNA, Small,stRNA,Small Temporal RNA,pre-miRNA,pre miRNA
Description
MicroRNAs: Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
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